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Mission Autonomy for Air and Space Systems (MASS) will be a one step, Closed BAA to develop multi-domain, multi-platform, multi-scale technologies and strategies to effectively apply closed-loop sensing, data processing, and reasoning capabilities to support sensing mission autonomy across the range of military operations. MASS delivered capabilities will enable knowledge management supporting understanding of the operating environment, including threats, allies, and neutral elements, and inform the planning, conduct, and assessment of mission effects, across multiple ISR, strike, EW and cyber missions. Technology investments under MASS must be compatible with Air Force missions for highly contested operating environments and address Architectural Agility, Mission Context Representation, Multisource Analytics, Sensing and Computational Resource Allocation, and Foundational Research as a scientific or technical basis for increasing novelty and versatility and reducing vulnerability of future transitionable sensing and knowledge management capabilities.